Supplements
Nothing here is approved for MCAS, and almost nothing has been tested in it. Every entry borrows its evidence from somewhere else. What differs is where from. Where no clinical sequence sets an order, an internal rank uses the strongest cited study design that directly involved mast cells. That affects browsing order only, not clinical importance. Each card shows the relationship and study types directly, plus any conditions actually approved or trialled.
8 entries. No dosing, and no claim that anything here works. How this is decided.
Outside that sequence — not part of the stepwise approach the review describes
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Epigallocatechin gallate Catechin polyphenol
How it relates: Mast cells in the laboratory Study types: Human mast cells in vitro
Green-tea catechin reported to reduce high-affinity IgE-receptor expression in a human mast-cell line; no clinical MCAS outcomes.
Recently verified. Verified 21 Aug 2026
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Luteolin Flavonoid
How it relates: Mast cells in the laboratory Study types: Human mast cells in vitro
Dietary flavonoid studied alongside quercetin for effects on mast cell mediator release in laboratory models.
Recently verified. Verified 20 Aug 2026
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Methoxyluteolin Methylated flavone
How it relates: Mast cells in the laboratory Study types: Human mast cells in vitro
Methylated flavone studied in cultured human mast cells; chemically distinct from luteolin, with no human outcome data in any condition.
- Approved for
- nothing — No regulatory approval
Recently verified. Verified 25 Aug 2026
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Quercetin Flavonoid
How it relates: Mast cells in the laboratory Study types: Human mast cells in vitro
Dietary flavonoid reported to inhibit mast cell mediator release in laboratory models; randomised human trials exist in allergic rhinitis, none in MCAS.
- Randomised trials in
- seasonal allergic rhinitis
Recently verified. Verified 25 Aug 2026
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Resveratrol Stilbene polyphenol
How it relates: Mast cells in the laboratory Study types: Human mast cells in vitro
Stilbene polyphenol studied in primary human intestinal and skin mast cells; laboratory effects differed by tissue, mediator, and exposure.
Recently verified. Verified 21 Aug 2026
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Rosmarinic-acid-enriched Perilla extract Rosmarinic-acid-enriched botanical extract
How it relates: Mast cells in the laboratory Study types: Human mast cells in vitro , Animal model
Defined Perilla leaf extract with rosmarinic-acid enrichment; human evidence is in seasonal allergy, while direct work on mast cells is laboratory-only.
- Randomised trials in
- seasonal allergic rhinoconjunctivitis
Recently verified. Verified 21 Aug 2026
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Palmitoylethanolamide (PEA) Fatty acid amide
How it relates: Mast cells in the laboratory Study types: Animal model
Endogenous fatty acid amide studied for effects on mast cell and glial activation in neuroinflammation models.
Recently verified. Verified 20 Aug 2026
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Diamine oxidase (DAO) Enzyme supplement
How it relates: Downstream of the mast cell Study types: Randomised controlled trial
Oral enzyme supplement intended to degrade histamine in the intestinal lumen before absorption.
- Randomised trials in
- chronic spontaneous urticaria
Recently verified. Verified 22 Aug 2026